U.S. Japan Seminar on molecular mechanisms of initiation, promotion progression.

U.S.-Japan Seminar on Molecular Mechanisms of Initiation, Promotion and Progression

This seminar was held on March 28 and 29, 1990 at the Senri Hankyu Hotel in Osaka, Japan. The organizers of this seminar were Dr. William F. Benedict, Center for Biotechnol ogy, Baylor College of Medicine, The Woodlands, TX; Dr. Curtis C. Harris, Laboratory of Human Carcinogenesis, Na tional Cancer Institute, Bethesda, MD; and Dr. Hirota Fujiki, Cancer Prevention Division, National Cancer Cente...

Molecular genetic control of leaf lifespan in plants - A review

Leaf senescence constitutes the last stage of leaf development in plants and proceeds through a highly regulated program in order to redistribution of micro- and macro-nutrients from the senescing leaves to the developing/growing plant organs. Initiation and progression of leaf senescence is accompanied by massive sequential alterations at various levels of leaf biology including leaf morpholog...

Alcohol and Cancer Stem Cells

Heavy alcohol consumption has been associated with increased risk of several cancers, including cancer of the colon, rectum, female breast, oral cavity, pharynx, larynx, liver, and esophagus. It appears that alcohol exposure not only promotes carcinogenesis but also enhances the progression and aggressiveness of existing cancers. The molecular mechanisms underlying alcohol tumor promotion, howe...

U.S. - Japan joint seminar on dynamic aspects of speech production: 'Key-note speech'

Ursodeoxycholic acid inhibits the initiation and postinitiation phases of azoxymethane-induced colonic tumor development.

Colonic tumorigenesis involves the processes of initiation and promotion/progression from normal epithelial cells to tumors. Studies in both humans and experimental models of colon cancer indicate that secondary bile acids promote tumor development. In contrast, we have demonstrated previously that another bile acid, ursodeoxycholic acid (UDCA), inhibits the development of azoxymethane (AOM)-in...